By Hershel Toomim (about the author) Page 2 of 4 page(s)
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These SPECT studies are compared to an age related, standardized
data. The false color blood fl ow levels are shown by colors ranging
from purple (unusually low) through white (unusually high). The scale
on the left side of the images shows z-scores (standard deviations)
from the mean. The population mean is depicted in yellow. The left
margin color scale defi nes standard deviations relative to the
population mean.
This pre-treatment study of a bipolar,
manic-depressive patient shows several seriously hypoperfused areas
(Heuser et al. 1994). These include the medial frontal subgenual
region, the right and left temporal lobes, both hippocampi, Broca's and
Werneke's areas as well as the left superior frontal and parietal
association areas.
Not shown in this view is the blue to purple right subgenual
orbital-frontal lobe. As Drevets (Drevets et al 1999), showed, this
area, when below normal, is common to bipolar disorder and depression
(Ito et al. 1996). The right orbital-frontal area, a gateway between
cortex and the limbic system, seems to provide cortical control of
emotion. Such control is lacking in bipolar disorder. In this emotional
vein we have yet to see a bipolar patient who has a good relationship
with her mother.
This study (Fig 4) was completed after 23 HEG sessions, 7/21/2000. As
of this writing this patient, previously a rapid cycler, has not
experienced a manic episode. At the time of this SPECT study she was
depressed. That this is to be expected is shown by the below normal
blue area in her left frontal cortex.
At present she is coping competently with her mother's newly diagnosed
metastasized breast cancer. She is a nurse and is too busy to feel
depressed. This is interesting since she has never before been able to
live peacefully with her mother.
Literature study examines brain areas involved in ADD/ADHD, Schizophrenia, and Autism.

Fig. 5
The National Library of Medicine search turned up many imaging studies of Autism, Schizophrenia and ADD/
ADHD disorders (Andreason et al.). The citation frequency for hypoperfused brain modules is illustrated here.
It is clear that hypoperfused frontal cortex dominates the fi eld.
Knowledge of the distribution of hypoperfused areas is useful in
determining brain areas to be treated.
The dominance and importance of frontal hypoperfusion fi ts our
experience in dealing with Depression (Drevets et al 1999), Toxic
Encephalopathy (Heuser et al. 1994), Epilepsy and Schizophrenia
(Andreason et al. 1997) as well. The importance of the frontal lobes
cannot be over emphasized (Ito et al. 1996). These areas are
particularly easy to reach from the forehead with the spectrophotometer
headband.
Disorders with Abnormal Regional Blood flow:
- ADD Senile Dementia
- Aging Memory Loss Dyslexia
- Alzheimer's Disease Epilepsy
- Anorexia /Bulimia Lupus Erythematosus
- Aspberger's Migraine
- Autism Multiple Sclerosis
- Chronic Fatigue Schizophrenia
- Depression Toxic Encepathalopathy
Test of Variables of Attention. (T.O.V.A.) A computerized test that
measures response time, consistency, inattention, and impulsivity.
The TOVA is useful in tracking patient recovery. Frontal cortex,
the executive part of the brain is most often compromised in any brain
disorder. The TOVA indicators, speed of response and stability of the
prefrontal cortex, are a useful index of improvement of brain function
following HEG neurotherapy. Many brain studies have validated the
proposition that healthy brains respond to problem solving and other
stimuli more rapidly than compromised brains. Thus working memory
problems are suitably tracked with TOVA to determine the most
appropriate dose for ADD/ADHD children.
Each study in the following graph used TOVA scores as a pre-post training measure. The graph shows the gains for all published studies with TOVA scores as the dependent variable

Fig. 6
Treatment TOVA gains per session vs. initial TOVA
scores for various treatments reported in the Neurofeedback literature.
There are EEG, Audio-Visual Stimulation (AVS), and HEG studies
presented. The number of sessions ranged from 10 to 40 in these studies.
The
TOVA gains per session of these published studies (Kaiser 1997, Kaiser
Othmer 1997, Thompson & Thompson 1998, Joyce & Siever 1997,
Rossiter 1995 1996, Joyce, 1997) present some very counterintuitive
information.
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Lifetime in innovative research resulting in many honors, patents, and pioneering development of biofeedback computer based instrumentation including Biocomp 2010 followed by invention of hemoencephalography (HEG)
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